Antitumor effects and molecular mechanisms of figitumumab, a humanized monoclonal antibody to IGF-1 receptor, in esophageal carcinoma

The insulin-like growth factor type 1 receptor (IGF-1R) plays an essential role in the development of numerous cancers. Figitumumab (CP) is not only a monocloncal antibody, it also has agonist activity on IGF-1R. The antitumor activity of CP in esophageal squamous cell carcinoma (ESCC) is still uncl...

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Detalles Bibliográficos
Autores principales: Zhang, Tiehong, Shen, Hongchang, Dong, Wei, Qu, Xiao, Liu, Qi, Du, Jiajun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215295/
https://www.ncbi.nlm.nih.gov/pubmed/25358597
http://dx.doi.org/10.1038/srep06855

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215295/
https://www.ncbi.nlm.nih.gov/pubmed/25358597
http://dx.doi.org/10.1038/srep06855

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