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Antitumor effects and molecular mechanisms of figitumumab, a humanized monoclonal antibody to IGF-1 receptor, in esophageal carcinoma

The insulin-like growth factor type 1 receptor (IGF-1R) plays an essential role in the development of numerous cancers. Figitumumab (CP) is not only a monocloncal antibody, it also has agonist activity on IGF-1R. The antitumor activity of CP in esophageal squamous cell carcinoma (ESCC) is still uncl...

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Detalles Bibliográficos
Autores principales:	Zhang, Tiehong, Shen, Hongchang, Dong, Wei, Qu, Xiao, Liu, Qi, Du, Jiajun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215295/ https://www.ncbi.nlm.nih.gov/pubmed/25358597 http://dx.doi.org/10.1038/srep06855

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