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Two novel DNA motifs are essential for BACE1 gene transcription
BACE1 gene encodes for β-Site amyloid β precursor protein (APP)-cleaving enzyme1, which is required for generating amyloid β protein(Aβ). Deposition of Aβ in brain plays an essential role in Alzheimer's Disease (AD) pathogenesis. BACE1 gene has a tissue-specific expression pattern and its expre...
Autores principales: | Xiang, Yan, Meng, Shasha, Wang, Jinfeng, Li, Songyang, Liu, Jingru, Li, Hongmei, Li, Tingyu, Song, Weihong, Zhou, Weihui |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215305/ https://www.ncbi.nlm.nih.gov/pubmed/25359283 http://dx.doi.org/10.1038/srep06864 |
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