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Covalent modification of cytoskeletal proteins in neuronal cells by tryptamine-4,5-dione

Serotonin, 5-hydroxytryptamine, is a systemic bioactive amine that acts in the gut and brain. As a substrate of myeloperoxidase in vitro, serotonin is oxidized to tryptamine-4,5-dione (TD), which is highly reactive with thiols. In this work, we successively prepared a monoclonal antibody to quinone-...

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Detalles Bibliográficos
Autores principales: Kato, Yoji, Ono, Shigeki, Kitamoto, Noritoshi, Kettle, Anthony J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215393/
https://www.ncbi.nlm.nih.gov/pubmed/25460734
http://dx.doi.org/10.1016/j.redox.2014.08.004