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SGTA regulates the cytosolic quality control of hydrophobic substrates

Hydrophobic amino acids are normally shielded from the cytosol and their exposure is often used as an indicator of protein misfolding to enable the chaperone-mediated recognition and quality control of aberrant polypeptides. Mislocalised membrane proteins (MLPs) represent a particular challenge to c...

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Detalles Bibliográficos
Autores principales: Wunderley, Lydia, Leznicki, Pawel, Payapilly, Aishwarya, High, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215715/
https://www.ncbi.nlm.nih.gov/pubmed/25179605
http://dx.doi.org/10.1242/jcs.155648