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Late cardiac sodium current can be assessed using automated patch-clamp

The cardiac late Na (+) current is generated by a small fraction of voltage-dependent Na (+) channels that undergo a conformational change to a burst-gating mode, with repeated openings and closures during the action potential (AP) plateau. Its magnitude can be augmented by inactivation-defective mu...

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Detalles Bibliográficos
Autores principales: Chevalier, Morgan, Amuzescu, Bogdan, Gawali, Vaibhavkumar, Todt, Hannes, Knott, Thomas, Scheel, Olaf, Abriel, Hugues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000Research 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215750/
https://www.ncbi.nlm.nih.gov/pubmed/25383189
http://dx.doi.org/10.12688/f1000research.5544.1