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Late cardiac sodium current can be assessed using automated patch-clamp
The cardiac late Na (+) current is generated by a small fraction of voltage-dependent Na (+) channels that undergo a conformational change to a burst-gating mode, with repeated openings and closures during the action potential (AP) plateau. Its magnitude can be augmented by inactivation-defective mu...
Autores principales: | Chevalier, Morgan, Amuzescu, Bogdan, Gawali, Vaibhavkumar, Todt, Hannes, Knott, Thomas, Scheel, Olaf, Abriel, Hugues |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
F1000Research
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215750/ https://www.ncbi.nlm.nih.gov/pubmed/25383189 http://dx.doi.org/10.12688/f1000research.5544.1 |
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