Agonist and antagonist binding to the nuclear vitamin D receptor: dynamics, mutation effects and functional implications

PURPOSE: The thermodynamically favored complex between the nuclear vitamin D receptor (VDR) and 1α,25(OH)(2)-vitamin D(3) (1,25D3) triggers a shift in equilibrium to favor VDR binding to DNA, heterodimerization with the nuclear retinoid x receptor (RXR) and subsequent regulation of gene transcriptio...

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Detalles Bibliográficos
Autores principales: Yaghmaei, Sepideh, Roberts, Christopher, Ai, Rizi, Mizwicki, Mathew T, Chang, Chia-en A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215818/
https://www.ncbi.nlm.nih.gov/pubmed/25505647
http://dx.doi.org/10.1186/2193-9616-1-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215818/
https://www.ncbi.nlm.nih.gov/pubmed/25505647
http://dx.doi.org/10.1186/2193-9616-1-2

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