Cargando…

Complex Impacts of PI3K/AKT Inhibitors to Androgen Receptor Gene Expression in Prostate Cancer Cells

BACKGROUND: Androgen deprivation therapy (ADT) is the first-line treatment to metastatic prostate cancer (PCa). However, sustained expression and function of the androgen receptor (AR) gene contribute to the progression of castration resistant prostate cancers (CRPC). Additionally, tumors can adapt...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Liangliang, Dong, Xuesen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215833/ https://www.ncbi.nlm.nih.gov/pubmed/25360799 http://dx.doi.org/10.1371/journal.pone.0108780

Ejemplares similares

Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways
por: Lu, Xinxing, et al.
Publicado: (2020)

Catalytic inhibitors of DNA topoisomerase II suppress the androgen receptor signaling and prostate cancer progression
por: Li, Haolong, et al.
Publicado: (2015)

Implications of PI3K/AKT inhibition on REST protein stability and neuroendocrine phenotype acquisition in prostate cancer cells
por: Chen, Ruiqui, et al.
Publicado: (2017)

PI3K-AKT-mTOR Pathway is Dominant over Androgen Receptor Signaling in Prostate Cancer Cells
por: Kaarbø, Mari, et al.
Publicado: (2010)

Correction: Implications of PI3K/AKT inhibition on REST protein stability and neuroendocrine phenotype acquisition in prostate cancer cells
por: Chen, Ruiqi, et al.
Publicado: (2018)

Osteopontin-c mediates the upregulation of androgen responsive genes in LNCaP cells through PI3K/Akt and androgen receptor signaling
por: TILLI, TATIANA MARTINS, et al.
Publicado: (2015)

Characterization of a Prostate- and Prostate Cancer-Specific Circular RNA Encoded by the Androgen Receptor Gene
por: Luo, Jindan, et al.
Publicado: (2019)

PI3K-AKT-mTOR signaling in prostate cancer progression and androgen deprivation therapy resistance
por: Edlind, Merritt P, et al.
Publicado: (2014)

The Androgen Receptor and Its Crosstalk With the Src Kinase During Castrate-Resistant Prostate Cancer Progression
por: Gao, Lin, et al.
Publicado: (2022)

SMAD3 promotes expression and activity of the androgen receptor in prostate cancer
por: Jeon, Hee-Young, et al.
Publicado: (2023)

The Role of Polymorphisms in Genes of PI3K/Akt Signaling Pathway on Prostate
por: Xu, Wei, et al.
Publicado: (2019)

Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells
por: Adediran, Samusi, et al.
Publicado: (2022)

Inhibitors of the PI3K/Akt/mTOR Pathway in Prostate Cancer Chemoprevention and Intervention
por: Roudsari, Nazanin Momeni, et al.
Publicado: (2021)

BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
por: Zhu, Sen, et al.
Publicado: (2018)

Novel therapeutic avenues in triple-negative breast cancer: PI3K/AKT inhibition, androgen receptor blockade, and beyond
por: Chan, Jack J., et al.
Publicado: (2019)

Testosterone Promotes the Proliferation of Chicken Embryonic Myoblasts Via Androgen Receptor Mediated PI3K/Akt Signaling Pathway
por: Li, Dongfeng, et al.
Publicado: (2020)

Effects of Androgen Receptor and Androgen on Gene Expression in Prostate Stromal Fibroblasts and Paracrine Signaling to Prostate Cancer Cells
por: Tanner, Matthew J., et al.
Publicado: (2011)

Androgen Receptor and PI3K Pathway Activity in Ovarian Cancer
por: Hill, Addie, et al.
Publicado: (2019)

PIK3CA mutations in androgen receptor-positive triple negative breast cancer confer sensitivity to the combination of PI3K and androgen receptor inhibitors
por: Lehmann, Brian D, et al.
Publicado: (2014)

Resveratrol inhibits proliferation and promotes apoptosis via the androgen receptor splicing variant 7 and PI3K/AKT signaling pathway in LNCaP prostate cancer cells
por: Ye, Mushi, et al.
Publicado: (2020)

Regulation of expression of Na(+),K(+)-ATPase in androgen-dependent and androgen-independent prostate cancer
por: Blok, L J, et al.
Publicado: (1999)

CYCLIN K down-regulation induces androgen receptor gene intronic polyadenylation, variant expression and PARP inhibitor vulnerability in castration-resistant prostate cancer
por: Sun, Rui, et al.
Publicado: (2022)

Taraxasterol suppresses the proliferation and tumor growth of androgen-independent prostate cancer cells through the FGFR2-PI3K/AKT signaling pathway
por: Yang, Jinqiu, et al.
Publicado: (2023)

Clinical values of expression signature of circCDR1AS and circHIAT1 in prostate cancer: Two circRNAs with regulatory function in androgen receptor (AR) and PI3K/AKT signaling pathways
por: Aghajani Mir, Mahsa, et al.
Publicado: (2022)

Targeting AKT1-E17K and the PI3K/AKT Pathway with an Allosteric AKT Inhibitor, ARQ 092
por: Yu, Yi, et al.
Publicado: (2015)

Reciprocal feedback inhibition of the androgen receptor and PI3K as a novel therapy for castrate-sensitive and -resistant prostate cancer
por: Qi, Wenqing, et al.
Publicado: (2015)

Impact of Androgen Receptor Activity on Prostate-Specific Membrane Antigen Expression in Prostate Cancer Cells
por: Sommer, Ulrich, et al.
Publicado: (2022)

Androgen Receptor-Induced Integrin α6β1 and Bnip3 Promotes Survival and Resistance to PI3K Inhibitors in Castration-Resistant Prostate Cancer
por: Nollet, Eric A., et al.
Publicado: (2020)

PI3K/Akt/mTOR inhibitors in breast cancer
por: Lee, Joycelyn JX, et al.
Publicado: (2015)

Overview on the complexity of androgen receptor-targeted therapy for prostate cancer
por: Farooqi, Ammad Ahmad, et al.
Publicado: (2015)

Prognostic impact of dose reduction in androgen receptor pathway inhibitors for castration-resistant prostate cancer
por: Yamada, Shigetomo, et al.
Publicado: (2022)

Androgen receptor gene amplification and protein expression in hormone refractory prostate cancer
por: Edwards, J, et al.
Publicado: (2003)

Complex Systems Biology Approach in Connecting PI3K-Akt and NF-κB Pathways in Prostate Cancer
por: Shankar, Eswar, et al.
Publicado: (2019)

LSD1 Activates PI3K/AKT Signaling Through Regulating p85 Expression in Prostate Cancer Cells
por: Wang, Zifeng, et al.
Publicado: (2019)

Development of an Androgen Receptor Inhibitor Targeting the N-Terminal Domain of Androgen Receptor for Treatment of Castration Resistant Prostate Cancer
por: Ban, Fuqiang, et al.
Publicado: (2021)

Isorhamnetin inhibited the proliferation and metastasis of androgen-independent prostate cancer cells by targeting the mitochondrion-dependent intrinsic apoptotic and PI3K/Akt/mTOR pathway
por: Cai, Fangzhen, et al.
Publicado: (2020)

Association of polymorphisms of PTEN, AKT1, PI3K, AR, and AMACR genes in patients with prostate cancer
por: de Nóbrega, Monyse, et al.
Publicado: (2020)

Comparing PI3K/Akt Inhibitors Used in Ovarian Cancer Treatment
por: Wu, Yi-Hui, et al.
Publicado: (2020)

The androgen receptor—lncRNASAT1-AKT-p15 axis mediates androgen-induced cellular senescence in prostate cancer cells
por: Mirzakhani, Kimia, et al.
Publicado: (2021)

PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition
por: Triscott, Joanna, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ca3inpag42o45se7fbmiat32lk