Application of Screening Experimental Designs to Assess Chromatographic Isotope Effect upon Isotope-Coded Derivatization for Quantitative Liquid Chromatography–Mass Spectrometry

[Image: see text] Isotope effect may cause partial chromatographic separation of labeled (heavy) and unlabeled (light) isotopologue pairs. Together with a simultaneous matrix effect, this could lead to unacceptable accuracy in quantitative liquid chromatography–mass spectrometry assays, especially w...

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Detalles Bibliográficos
Autores principales: Szarka, Szabolcs, Prokai-Tatrai, Katalin, Prokai, Laszlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215859/
https://www.ncbi.nlm.nih.gov/pubmed/24922593
http://dx.doi.org/10.1021/ac501309s

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215859/
https://www.ncbi.nlm.nih.gov/pubmed/24922593
http://dx.doi.org/10.1021/ac501309s

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