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MultiNotch MS3 Enables Accurate, Sensitive, and Multiplexed Detection of Differential Expression across Cancer Cell Line Proteomes

[Image: see text] Multiplexed quantitation via isobaric chemical tags (e.g., tandem mass tags (TMT) and isobaric tags for relative and absolute quantitation (iTRAQ)) has the potential to revolutionize quantitative proteomics. However, until recently the utility of these tags was questionable due to...

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Detalles Bibliográficos
Autores principales: McAlister, Graeme C., Nusinow, David P., Jedrychowski, Mark P., Wühr, Martin, Huttlin, Edward L., Erickson, Brian K., Rad, Ramin, Haas, Wilhelm, Gygi, Steven P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215866/
https://www.ncbi.nlm.nih.gov/pubmed/24927332
http://dx.doi.org/10.1021/ac502040v