Dose Schedule Optimization and the Pharmacokinetic Driver of Neutropenia

Toxicity often limits the utility of oncology drugs, and optimization of dose schedule represents one option for mitigation of this toxicity. Here we explore the schedule-dependency of neutropenia, a common dose-limiting toxicity. To this end, we analyze previously published mathematical models of n...

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Detalles Bibliográficos
Autores principales: Patel, Mayankbhai, Palani, Santhosh, Chakravarty, Arijit, Yang, Johnny, Shyu, Wen Chyi, Mettetal, Jerome T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215876/
https://www.ncbi.nlm.nih.gov/pubmed/25360756
http://dx.doi.org/10.1371/journal.pone.0109892

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215876/
https://www.ncbi.nlm.nih.gov/pubmed/25360756
http://dx.doi.org/10.1371/journal.pone.0109892

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