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Dose Schedule Optimization and the Pharmacokinetic Driver of Neutropenia
Toxicity often limits the utility of oncology drugs, and optimization of dose schedule represents one option for mitigation of this toxicity. Here we explore the schedule-dependency of neutropenia, a common dose-limiting toxicity. To this end, we analyze previously published mathematical models of n...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215876/ https://www.ncbi.nlm.nih.gov/pubmed/25360756 http://dx.doi.org/10.1371/journal.pone.0109892 |