Drug-resistance of a viral population and its individual intra-host variants during the first 48 hours of therapy

Using HCV and IFN-resistance as a proof of concept, we have devised a new methodology for calculating the effect of a drug over a viral population and the resistance of its individual intra-host variants. By means of next-generation sequencing, HCV variants were obtained from sera collected at 9 tim...

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Detalles Bibliográficos
Autores principales: Campo, David S., Skums, Pavel, Dimitrova, Zoya, Vaughan, Gilberto, Forbi, Joseph C., Teo, Chong-Gee, Khudyakov, Yury, Lau, Daryl T.-Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215939/
https://www.ncbi.nlm.nih.gov/pubmed/24488144
http://dx.doi.org/10.1038/clpt.2014.20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215939/
https://www.ncbi.nlm.nih.gov/pubmed/24488144
http://dx.doi.org/10.1038/clpt.2014.20

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