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Drug-resistance of a viral population and its individual intra-host variants during the first 48 hours of therapy
Using HCV and IFN-resistance as a proof of concept, we have devised a new methodology for calculating the effect of a drug over a viral population and the resistance of its individual intra-host variants. By means of next-generation sequencing, HCV variants were obtained from sera collected at 9 tim...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215939/ https://www.ncbi.nlm.nih.gov/pubmed/24488144 http://dx.doi.org/10.1038/clpt.2014.20 |