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Mechanism of error-free and semi-targeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4
The aromatic amine carcinogen 2-aminofluorene (AF) forms covalent adducts with DNA, predominantly with guanine at the C8 position. Such lesions are bypassed by Y-family polymerases such as Dpo4 via error-free and error-prone mechanisms. We show that Dpo4 catalyzes elongation from a correct 3′-termin...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2010
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4215948/ https://www.ncbi.nlm.nih.gov/pubmed/20154704 http://dx.doi.org/10.1038/nsmb.1771 |