Tumor Suppressors TSC1 and TSC2 Differentially Modulate Actin Cytoskeleton and Motility of Mouse Embryonic Fibroblasts

TSC1 and TSC2 mutations cause neoplasms in rare disease pulmonary LAM and neuronal pathfinding in hamartoma syndrome TSC. The specific roles of TSC1 and TSC2 in actin remodeling and the modulation of cell motility, however, are not well understood. Previously, we demonstrated that TSC1 and TSC2 regu...

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Detalles Bibliográficos
Autores principales: Goncharova, Elena A., James, Melane L., Kudryashova, Tatiana V., Goncharov, Dmitry A., Krymskaya, Vera P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216017/
https://www.ncbi.nlm.nih.gov/pubmed/25360538
http://dx.doi.org/10.1371/journal.pone.0111476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216017/
https://www.ncbi.nlm.nih.gov/pubmed/25360538
http://dx.doi.org/10.1371/journal.pone.0111476

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