P2Y(6) Receptor Potentiates Pro-Inflammatory Responses in Macrophages and Exhibits Differential Roles in Atherosclerotic Lesion Development

BACKGROUND: P2Y(6), a purinergic receptor for UDP, is enriched in atherosclerotic lesions and is implicated in pro-inflammatory responses of key vascular cell types and macrophages. Evidence for its involvement in atherogenesis, however, has been lacking. Here we use cell-based studies and three mur...

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Detalles Bibliográficos
Autores principales: Garcia, Ricardo A., Yan, Mujing, Search, Debra, Zhang, Rongan, Carson, Nancy L., Ryan, Carol S., Smith-Monroy, Constance, Zheng, Joanna, Chen, Jian, Kong, Yan, Tang, Huaping, Hellings, Samuel E., Wardwell-Swanson, Judith, Dinchuk, Joseph E., Psaltis, George C., Gordon, David A., Glunz, Peter W., Gargalovic, Peter S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216081/
https://www.ncbi.nlm.nih.gov/pubmed/25360548
http://dx.doi.org/10.1371/journal.pone.0111385

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216081/
https://www.ncbi.nlm.nih.gov/pubmed/25360548
http://dx.doi.org/10.1371/journal.pone.0111385

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