Evidence for a Catalytically and Kinetically Competent Enzyme–Substrate Cross-Linked Intermediate in Catalysis by Lipoyl Synthase

[Image: see text] Lipoyl synthase (LS) catalyzes the final step in lipoyl cofactor biosynthesis: the insertion of two sulfur atoms at C6 and C8 of an (N(6)-octanoyl)-lysyl residue on a lipoyl carrier protein (LCP). LS is a member of the radical SAM superfamily, enzymes that use a [4Fe–4S] cluster to...

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Detalles Bibliográficos
Autores principales: Lanz, Nicholas D., Pandelia, Maria-Eirini, Kakar, Elizabeth S., Lee, Kyung-Hoon, Krebs, Carsten, Booker, Squire J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216189/
https://www.ncbi.nlm.nih.gov/pubmed/24901788
http://dx.doi.org/10.1021/bi500432r

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216189/
https://www.ncbi.nlm.nih.gov/pubmed/24901788
http://dx.doi.org/10.1021/bi500432r

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