4-Amino-1-hydroxy-2-oxo-1,8-naphthyridine-Containing Compounds Having High Potency against Raltegravir-Resistant Integrase Mutants of HIV-1

[Image: see text] There are currently three HIV-1 integrase (IN) strand transfer inhibitors (INSTIs) approved by the FDA for the treatment of AIDS. However, the emergence of drug-resistant mutants emphasizes the need to develop additional agents that have improved efficacies against the existent res...

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Detalles Bibliográficos
Autores principales: Zhao, Xue Zhi, Smith, Steven J., Métifiot, Mathieu, Marchand, Christophe, Boyer, Paul L., Pommier, Yves, Hughes, Stephen H., Burke, Terrence R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216207/
https://www.ncbi.nlm.nih.gov/pubmed/24901667
http://dx.doi.org/10.1021/jm5001908

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216207/
https://www.ncbi.nlm.nih.gov/pubmed/24901667
http://dx.doi.org/10.1021/jm5001908

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