Dual Protonophore–Chitinase Inhibitors Dramatically Affect O. volvulus Molting

[Image: see text] The L3-stage-specific chitinase OvCHT1 has been implicated in the development of Onchocerca volvulus, the causative agent of onchocerciasis. Closantel, a known anthelmintic drug, was previously discovered as a potent and specific OvCHT1 inhibitor. As closantel is also a known proto...

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Detalles Bibliográficos
Autores principales: Gooyit, Major, Tricoche, Nancy, Lustigman, Sara, Janda, Kim D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216208/
https://www.ncbi.nlm.nih.gov/pubmed/24918716
http://dx.doi.org/10.1021/jm5006435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216208/
https://www.ncbi.nlm.nih.gov/pubmed/24918716
http://dx.doi.org/10.1021/jm5006435

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