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Dual Protonophore–Chitinase Inhibitors Dramatically Affect O. volvulus Molting
[Image: see text] The L3-stage-specific chitinase OvCHT1 has been implicated in the development of Onchocerca volvulus, the causative agent of onchocerciasis. Closantel, a known anthelmintic drug, was previously discovered as a potent and specific OvCHT1 inhibitor. As closantel is also a known proto...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216208/ https://www.ncbi.nlm.nih.gov/pubmed/24918716 http://dx.doi.org/10.1021/jm5006435 |