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KDM4B as a Target for Prostate Cancer: Structural Analysis and Selective Inhibition by a Novel Inhibitor

[Image: see text] The KDM4/JMJD2 Jumonji C-containing histone lysine demethylases (KDM4A–KDM4D), which selectively remove the methyl group(s) from tri/dimethylated lysine 9/36 of H3, modulate transcriptional activation and genome stability. The overexpression of KDM4A/KDM4B in prostate cancer and th...

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Detalles Bibliográficos
Autores principales: Chu, Chia-Han, Wang, Ling-Yu, Hsu, Kai-Cheng, Chen, Chung-Chin, Cheng, Hsing-Hung, Wang, Szu-Min, Wu, Chien-Ming, Chen, Tsan-Jan, Li, Ling-Ting, Liu, Ruiwu, Hung, Chiu-Lien, Yang, Jing-Moon, Kung, Hsing-Jien, Wang, Wen-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216216/
https://www.ncbi.nlm.nih.gov/pubmed/24971742
http://dx.doi.org/10.1021/jm500249n