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Tranylcypromine Substituted cis-Hydroxycyclobutylnaphthamides as Potent and Selective Dopamine D(3) Receptor Antagonists
[Image: see text] We report a class of potent and selective dopamine D(3) receptor antagonists based upon tranylcypromine. Although tranylcypromine has a low affinity for the rat D(3) receptor (K(i) = 12.8 μM), our efforts have yielded (1R,2S)-11 (CJ-1882), which has K(i) values of 2.7 and 2.8 nM at...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216217/ https://www.ncbi.nlm.nih.gov/pubmed/24848155 http://dx.doi.org/10.1021/jm401798r |