Molecular Systems Pharmacology: Isoelectric Focusing Signature of Protein Kinase Cδ Provides an Integrated Measure of Its Modulation in Response to Ligands

[Image: see text] Protein kinase C (PKC), a validated therapeutic target for cancer chemotherapy, provides a paradigm for assessing structure–activity relations, where ligand binding has multiple consequences for a target. For PKC, ligand binding controls not only PKC activation and multiple phospho...

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Detalles Bibliográficos
Autores principales: Kedei, Noemi, Chen, Jin-Qiu, Herrmann, Michelle A., Telek, Andrea, Goldsmith, Paul K., Petersen, Mark E., Keck, Gary E., Blumberg, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216220/
https://www.ncbi.nlm.nih.gov/pubmed/24906106
http://dx.doi.org/10.1021/jm500417b

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216220/
https://www.ncbi.nlm.nih.gov/pubmed/24906106
http://dx.doi.org/10.1021/jm500417b

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