Co-localization of cell death with antigen deposition in skin enhances vaccine immunogenicity

Vaccines delivered to the skin by microneedles – with and without adjuvants – have increased immunogenicity with lower doses than standard vaccine delivery techniques such as intramuscular (i.m.) or intradermal (i.d.) injection. However, the mechanisms behind this skin-mediated ‘adjuvant’ effect are...

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Detalles Bibliográficos
Autores principales: Depelsenaire, Alexandra C.I., Meliga, Stefano C., McNeilly, Celia L., Pearson, Frances E., Coffey, Jacob W., Haigh, Oscar L., Flaim, Christopher J., Frazer, Ian H., Kendall, Mark A.F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216316/
https://www.ncbi.nlm.nih.gov/pubmed/24714201
http://dx.doi.org/10.1038/jid.2014.174

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216316/
https://www.ncbi.nlm.nih.gov/pubmed/24714201
http://dx.doi.org/10.1038/jid.2014.174

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