Multiple factors influence the contribution of individual immunoglobulin light chain genes to the naïve antibody repertoire

BACKGROUND: The naïve antibody repertoire is initially dependent upon the number of germline V(D)J genes and the ability of recombined heavy and light chains to pair. Individual VH and VL genes are not equally represented in naïve mature B cells, suggesting that positive and negative selection also...

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Detalles Bibliográficos
Autores principales: Fitzsimmons, Sean P, Aydanian, Antonina G, Clark, Kathleen J, Shapiro, Marjorie A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216371/
https://www.ncbi.nlm.nih.gov/pubmed/25359572
http://dx.doi.org/10.1186/s12865-014-0051-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216371/
https://www.ncbi.nlm.nih.gov/pubmed/25359572
http://dx.doi.org/10.1186/s12865-014-0051-2

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