CREB mediates the insulinotropic and anti-apoptotic effects of GLP-1 signaling in adult mouse β-cells

OBJECTIVE: Glucagon-like peptide-1 (GLP-1) plays a major role in pancreatic β-cell function and survival by increasing cytoplasmic cAMP levels, which are thought to affect transcription through activation of the basic leucine zipper (bZIP) transcription factor CREB. Here, we test CREB function in th...

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Detalles Bibliográficos
Autores principales: Shin, Soona, Le Lay, John, Everett, Logan J., Gupta, Rana, Rafiq, Kiran, Kaestner, Klaus H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216406/
https://www.ncbi.nlm.nih.gov/pubmed/25379405
http://dx.doi.org/10.1016/j.molmet.2014.08.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216406/
https://www.ncbi.nlm.nih.gov/pubmed/25379405
http://dx.doi.org/10.1016/j.molmet.2014.08.001

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