Nuclear PRAS40 couples the Akt/mTORC1 signaling axis to the RPL11-HDM2-p53 nucleolar stress response pathway

The Ribosomal Protein (RP)-HDM2-p53 pathway has been shown to play key roles in oncogene-induced apoptosis and senescence, but the mechanism regulating this pathway remains elusive. The Proline-Rich Akt Substrate of 40 kDA (PRAS40) has recently been identified as a binding partner and inhibitor of t...

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Detalles Bibliográficos
Autores principales: Havel, Jonathan J., Li, Zenggang, Cheng, Dongmei, Peng, Junmin, Fu, Haian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216640/
https://www.ncbi.nlm.nih.gov/pubmed/24704832
http://dx.doi.org/10.1038/onc.2014.91

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216640/
https://www.ncbi.nlm.nih.gov/pubmed/24704832
http://dx.doi.org/10.1038/onc.2014.91

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