Cargando…

Downregulation of MDR1 Gene by Cepharanthine Hydrochloride Is Related to the Activation of c-Jun/JNK in K562/ADR Cells

The purpose of the study was to determine the signal transduction mechanism of cepharanthine hydrochloride (CH) on reversing tumor multidrug resistance. RT-PCR and Western blot analysis were used to determine the effects of CH on the expression of MDR1 mRNA and P-glycoprotein in K562/ADR cells when...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Li, Wang, Yafeng, Guo, Xiaojuan, Zhou, Yubing, Zhang, Jingmin, Wang, Ning, Jiang, Jinhua, Ma, Fang, Wang, Qingduan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216687/ https://www.ncbi.nlm.nih.gov/pubmed/25386557 http://dx.doi.org/10.1155/2014/164391

Ejemplares similares

Retracted: Downregulation of MDR1 Gene by Cepharanthine Hydrochloride Is Related to the Activation of c-Jun/JNK in K562/ADR Cells
por: International, BioMed Research
Publicado: (2016)

Effect of CIK on multidrug-resistance reversal and increasing the sensitivity of ADR in K562/ADR cells
por: WANG, LEI, et al.
Publicado: (2014)

Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals
por: Zhou, Pengjun, et al.
Publicado: (2017)

Correction: Cepharanthine hydrochloride reverses the mdr1 (P-glycoprotein)-mediated esophageal squamous cell carcinoma cell cisplatin resistance through JNK and p53 signals
por: Zhou, Pengjun, et al.
Publicado: (2021)

Usnea Acid as Multidrug Resistance (MDR) Reversing Agent against Human Chronic Myelogenous Leukemia K562/ADR Cells via an ROS Dependent Apoptosis
por: Wang, Wenjing, et al.
Publicado: (2019)

Tuberostemonine reverses multidrug resistance in chronic myelogenous leukemia cells K562/ADR
por: Wang, Yu Jia, et al.
Publicado: (2017)

Corrigendum to “Usnea Acid as Multidrug Resistance (MDR) Reversing Agent against Human Chronic Myelogenous Leukemia K562/ADR Cells via an ROS Dependent Apoptosis”
por: Wang, Wenjing, et al.
Publicado: (2021)

Novel fluoronucleoside analog NCC inhibits lamivudine-resistant hepatitis B virus in a hepatocyte model
por: Zhang, Jingmin, et al.
Publicado: (2018)

Cepharanthine Hydrochloride Improves Cisplatin Chemotherapy and Enhances Immunity by Regulating Intestinal Microbes in Mice
por: Zhou, Pengjun, et al.
Publicado: (2019)

Cepharanthine hydrochloride inhibits the Wnt/β-catenin/Hedgehog signaling axis in liver cancer
por: Su, Gui-Feng, et al.
Publicado: (2022)

Artesunate enhances adriamycin cytotoxicity by inhibiting glycolysis in adriamycin-resistant chronic myeloid leukemia K562/ADR cells
por: Chen, Li, et al.
Publicado: (2019)

Differential chemosensitization of P-glycoprotein overexpressing K562/Adr cells by withaferin A and Siamois polyphenols
por: Suttana, Wipob, et al.
Publicado: (2010)

Analysis of ceRNA networks and identification of potential drug targets for drug-resistant leukemia cell K562/ADR
por: Liu, Zhaoping, et al.
Publicado: (2021)

Silencing of ETS1 reverses adriamycin resistance in MCF-7/ADR cells via downregulation of MDR1
por: Wei, Jinrong, et al.
Publicado: (2014)

Apoptosis Sensitization by Euphorbia Factor L1 in ABCB1-Mediated Multidrug Resistant K562/ADR Cells
por: Zhang, Jian-Ye, et al.
Publicado: (2013)

In vitro activity of cepharanthine hydrochloride against clinical wild-type and lamivudine-resistant hepatitis B virus isolates
por: Zhou, Yu-Bing, et al.
Publicado: (2012)

Pharmacological Activity of Cepharanthine
por: Liu, Ke, et al.
Publicado: (2023)

Involvement of CD147 on multidrug resistance through the regulation of P-glycoprotein expression in K562/ADR leukemic cell line
por: Somno, Aoranit, et al.
Publicado: (2016)

Molecular Mechanism of Matrine from Sophora alopecuroides in the Reversing Effect of Multi-Anticancer Drug Resistance in K562/ADR Cells
por: Chen, Zhi, et al.
Publicado: (2019)

Cepharanthine in Experimental Tuberculosis
por: Sirsi, M., et al.
Publicado: (1952)

Silencing of the CrkL gene reverses the doxorubicin resistance of K562/ADR cells through regulating PI3K/Akt/MRP1 signaling
por: Yu, Jiang, et al.
Publicado: (2021)

Pinellia pedatisecta Agglutinin Targets Drug Resistant K562/ADR Leukemia Cells through Binding with Sarcolemmal Membrane Associated Protein and Enhancing Macrophage Phagocytosis
por: Chen, Kan, et al.
Publicado: (2013)

Network Characteristic Analysis of ADR-related Proteins and Identification of ADR-ADR Associations
por: Chen, Xiujie, et al.
Publicado: (2013)

Pentagalloyl Glucose-Targeted Inhibition of P-Glycoprotein and Re-Sensitization of Multidrug-Resistant Leukemic Cells (K562/ADR) to Doxorubicin: In Silico and Functional Studies
por: Dechsupa, Nathupakorn, et al.
Publicado: (2023)

In vitro antiplasmodial activity of cepharanthine
por: Desgrouas, Camille, et al.
Publicado: (2014)

Hypericin-mediated photodynamic therapy induces apoptosis in K562 human leukemia cells through JNK pathway modulation
por: XU, YIXIAO, et al.
Publicado: (2015)

Knockdown of ZNF268, which Is Transcriptionally Downregulated by GATA-1, Promotes Proliferation of K562 Cells
por: Zeng, Yan, et al.
Publicado: (2012)

Using Rhodamine 123 Accumulation in CD8(+) Cells as a Surrogate Indicator to Study the P-Glycoprotein Modulating Effect of Cepharanthine Hydrochloride In Vivo
por: Li, Han, et al.
Publicado: (2011)

The miR-203a Regulatory Network Affects the Proliferation of Chronic Myeloid Leukemia K562 Cells
por: He, Jinhua, et al.
Publicado: (2021)

Pharmacological Effects and Clinical Prospects of Cepharanthine
por: Liang, Di, et al.
Publicado: (2022)

In Vitro Antileukemia Activity of ZSTK474 on K562 and Multidrug Resistant K562/A02 Cells
por: Zhou, Qianxiang, et al.
Publicado: (2016)

8-Hydroxydaidzein Downregulates JAK/STAT, MMP, Oxidative Phosphorylation, and PI3K/AKT Pathways in K562 Cells
por: Wu, Pei-Shan, et al.
Publicado: (2021)

miRNA143 Induces K562 Cell Apoptosis Through Downregulating BCR-ABL
por: Liang, Bing, et al.
Publicado: (2016)

Knockdown of SALL4 inhibits the proliferation and reverses the resistance of MCF-7/ADR cells to doxorubicin hydrochloride
por: Chen, Yuan-Yuan, et al.
Publicado: (2016)

Novel peptide myristoly-CM4 induces selective cytotoxicity in leukemia K562/MDR and Jurkat cells by necrosis and/or apoptosis pathway
por: Zhang, Huidan, et al.
Publicado: (2019)

CAMSAP2 promotes colorectal cancer cell migration and invasion through activation of JNK/c-Jun/MMP-1 signaling pathway
por: Wang, Xiaojuan, et al.
Publicado: (2022)

Cepharanthine Suppresses Herpes Simplex Virus Type 1 Replication Through the Downregulation of the PI3K/Akt and p38 MAPK Signaling Pathways
por: Liu, Yao, et al.
Publicado: (2021)

Rapamycin enhanced the antitumor effects of doxorubicin in myelogenous leukemia K562 cells by downregulating the mTOR/p70S6K pathway
por: Li, Jie, et al.
Publicado: (2019)

Thymoquinone Induces Downregulation of BCR-ABL/JAK/STAT Pathway and Apoptosis in K562 Leukemia Cells
por: Al-Rawashde, Futoon Abedrabbu, et al.
Publicado: (2021)

MALT1 promotes melanoma progression through JNK/c-Jun signaling
por: Wang, Y, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_6o5k66u4e7p717pghn4tjqbh01