Genetic and environmental exposures constrain epigenetic drift over the human life course

Epigenetic mechanisms such as DNA methylation (DNAm) are essential for regulation of gene expression. DNAm is dynamic, influenced by both environmental and genetic factors. Epigenetic drift is the divergence of the epigenome as a function of age due to stochastic changes in methylation. Here we show...

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Detalles Bibliográficos
Autores principales: Shah, Sonia, McRae, Allan F., Marioni, Riccardo E., Harris, Sarah E., Gibson, Jude, Henders, Anjali K., Redmond, Paul, Cox, Simon R., Pattie, Alison, Corley, Janie, Murphy, Lee, Martin, Nicholas G., Montgomery, Grant W., Starr, John M., Wray, Naomi R., Deary, Ian J., Visscher, Peter M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216914/
https://www.ncbi.nlm.nih.gov/pubmed/25249537
http://dx.doi.org/10.1101/gr.176933.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216914/
https://www.ncbi.nlm.nih.gov/pubmed/25249537
http://dx.doi.org/10.1101/gr.176933.114

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