Cell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing

It remains an open question when and how the first cell fate decision is made in mammals. Using deep single-cell RNA-seq of matched sister blastomeres, we report highly reproducible inter-blastomere differences among 10 2-cell and five 4-cell mouse embryos. Inter-blastomere gene expression differenc...

Descripción completa

Detalles Bibliográficos
Autores principales: Biase, Fernando H., Cao, Xiaoyi, Zhong, Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216920/
https://www.ncbi.nlm.nih.gov/pubmed/25096407
http://dx.doi.org/10.1101/gr.177725.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216920/
https://www.ncbi.nlm.nih.gov/pubmed/25096407
http://dx.doi.org/10.1101/gr.177725.114

Ejemplares similares