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Cell fate inclination within 2-cell and 4-cell mouse embryos revealed by single-cell RNA sequencing
It remains an open question when and how the first cell fate decision is made in mammals. Using deep single-cell RNA-seq of matched sister blastomeres, we report highly reproducible inter-blastomere differences among 10 2-cell and five 4-cell mouse embryos. Inter-blastomere gene expression differenc...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216920/ https://www.ncbi.nlm.nih.gov/pubmed/25096407 http://dx.doi.org/10.1101/gr.177725.114 |