Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model

Insertional leukemogenesis represents the major risk factor of hematopoietic stem cell (HSC) based gene therapy utilizing integrating viral vectors. To develop a pre-clinical model for the evaluation of vector-related genotoxicity directly in the relevant human target cells, cord blood CD34(+) HSCs...

Descripción completa

Detalles Bibliográficos
Autores principales: Haemmerle, Reinhard, Phaltane, Ruhi, Rothe, Michael, Schröder, Simon, Schambach, Axel, Moritz, Thomas, Modlich, Ute
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217076/
https://www.ncbi.nlm.nih.gov/pubmed/25291142
http://dx.doi.org/10.1038/mtna.2014.51

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217076/
https://www.ncbi.nlm.nih.gov/pubmed/25291142
http://dx.doi.org/10.1038/mtna.2014.51

Ejemplares similares