Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing

The DNA damage response (DDR) orchestrates DNA repair and halts cell cycle. If damage is not resolved, cells can enter into an irreversible state of proliferative arrest called cellular senescence. Organismal ageing in mammals is associated with accumulation of markers of cellular senescence and DDR...

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Detalles Bibliográficos
Autores principales: Rossiello, Francesca, Herbig, Utz, Longhese, Maria Pia, Fumagalli, Marzia, d’Adda di Fagagna, Fabrizio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217147/
https://www.ncbi.nlm.nih.gov/pubmed/25104620
http://dx.doi.org/10.1016/j.gde.2014.06.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217147/
https://www.ncbi.nlm.nih.gov/pubmed/25104620
http://dx.doi.org/10.1016/j.gde.2014.06.009

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