Effects of Repeated Intravenous Administration of Dextrans,Water-soluble Macromolecules, in Rats

We investigated the influence of repeated intravenous administration of dextrans (DEXs) to rats. Seven-week-old Sprague Dawley rats (6 males/group) were given intravenously 10% saline solutions of dextrans (DEXs), 40 kDa or 200–300 kDa, at a dose level of 5 mL/kg/day for 28 days and they were examin...

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Detalles Bibliográficos
Autores principales: Kitazawa, Ikue, Ito, Shino, Kagawa, Yusuke, Suehiro-Narita, Miki, Hashizume, Naoto, Minamisawa, Yuka, Nii, Aisuke, Kawakami, Akio, Nakajima, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society of Toxicologic Pathology 2014
Materias:
Technical Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217235/
https://www.ncbi.nlm.nih.gov/pubmed/25378808
http://dx.doi.org/10.1293/tox.2013-0067
Descripción
Sumario:We investigated the influence of repeated intravenous administration of dextrans (DEXs) to rats. Seven-week-old Sprague Dawley rats (6 males/group) were given intravenously 10% saline solutions of dextrans (DEXs), 40 kDa or 200–300 kDa, at a dose level of 5 mL/kg/day for 28 days and they were examined histopathologically. Another group (3 males/group) was administered saline in a similar manner and served as the control. Histopathological changes indicating accumulation of DEXs in the mononuclear phagocyte system (MPS) and the liver were noted in the treated groups. The incidence and severity of the findings were molecular weight-dependent, except for the lungs. These results are considered useful in interpreting data from preclinical studies, in which DEXs or their derivatives are administered as test or control substances.

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