Nucleosomal occupancy changes locally over key regulatory regions during cell differentiation and reprogramming

Chromatin structure determines DNA accessibility. We compare nucleosome occupancy in mouse and human embryonic stem cells (ESCs), induced-pluripotent stem cells (iPSCs) and differentiated cell types using MNase-seq. To address variability inherent in this technique, we developed a bioinformatic appr...

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Detalles Bibliográficos
Autores principales: West, Jason A., Cook, April, Alver, Burak H., Stadtfeld, Matthias, Deaton, Aimee M., Hochedlinger, Konrad, Park, Peter J., Tolstorukov, Michael Y., Kingston, Robert E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217530/
https://www.ncbi.nlm.nih.gov/pubmed/25158628
http://dx.doi.org/10.1038/ncomms5719

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