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TPX2 Impacts Acetylation of Histone H4 at Lysine 16: Implications for DNA Damage Response
During interphase, the spindle assembly factor TPX2 is compartmentalized in the nucleus where its roles remain largely uncharacterized. Recently, we found that TPX2 regulates the levels of serine 139-phosphoryated H2AX (γ-H2AX) at chromosomal breaks induced by ionizing radiation. Here, we report tha...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217740/ https://www.ncbi.nlm.nih.gov/pubmed/25365214 http://dx.doi.org/10.1371/journal.pone.0110994 |