The TLR4 D299G and T399I SNPs Are Constitutively Active to Up-Regulate Expression of Trif-Dependent Genes

Dysregulated Toll-Like Receptor (TLR) signalling and genetic polymorphisms in these proteins are linked to many human diseases. We investigated TLR4 functional variants D299G and T399I to assess the impact on LPS-induced responsiveness in comparison to wild-type TLR4. The mechanism by which this occ...

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Detalles Bibliográficos
Autores principales: Hold, Georgina L., Berry, Susan, Saunders, Karin A., Drew, Janice, Mayer, Claus, Brookes, Heather, Gay, Nick J., El-Omar, Emad M., Bryant, Clare E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218727/
https://www.ncbi.nlm.nih.gov/pubmed/25365308
http://dx.doi.org/10.1371/journal.pone.0111460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218727/
https://www.ncbi.nlm.nih.gov/pubmed/25365308
http://dx.doi.org/10.1371/journal.pone.0111460

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