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Generation of a Single Chain Antibody Variable Fragment (scFv) to Sense Selectively RhoB Activation
Determining the cellular level of activated form of RhoGTPases is of key importance to understand their regulatory functions in cell physiopathology. We previously reported scFvC1, that selectively bind to the GTP-bound form of RhoA, RhoB and RhoC. In this present study we generate, by molecular evo...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218836/ https://www.ncbi.nlm.nih.gov/pubmed/25365345 http://dx.doi.org/10.1371/journal.pone.0111034 |