Plk1 Inhibition Causes Post-Mitotic DNA Damage and Senescence in a Range of Human Tumor Cell Lines

Plk1 is a checkpoint protein whose role spans all of mitosis and includes DNA repair, and is highly conserved in eukaryotes from yeast to man. Consistent with this wide array of functions for Plk1, the cellular consequences of Plk1 disruption are diverse, spanning delays in mitotic entry, mitotic sp...

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Detalles Bibliográficos
Autores principales: Driscoll, Denise L., Chakravarty, Arijit, Bowman, Doug, Shinde, Vaishali, Lasky, Kerri, Shi, Judy, Vos, Tricia, Stringer, Bradley, Amidon, Ben, D'Amore, Natalie, Hyer, Marc L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218841/
https://www.ncbi.nlm.nih.gov/pubmed/25365521
http://dx.doi.org/10.1371/journal.pone.0111060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218841/
https://www.ncbi.nlm.nih.gov/pubmed/25365521
http://dx.doi.org/10.1371/journal.pone.0111060

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