Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells

Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly to the failure of existing therapies. Deregulation of small GTPases signaling, in particular Rac1 activity, plays a key role in the invasive phenotype o...

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Detalles Bibliográficos
Autores principales: Cardama, Georgina A, Gonzalez, Nazareno, Ciarlantini, Matias, Gandolfi Donadío, Lucia, Comin, María Julieta, Alonso, Daniel F, Menna, Pablo Lorenzano, Gomez, Daniel E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218912/
https://www.ncbi.nlm.nih.gov/pubmed/25378937
http://dx.doi.org/10.2147/OTT.S67998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218912/
https://www.ncbi.nlm.nih.gov/pubmed/25378937
http://dx.doi.org/10.2147/OTT.S67998

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