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Proapoptotic and antiinvasive activity of Rac1 small molecule inhibitors on malignant glioma cells
Malignant gliomas are characterized by an intrinsic ability to invade diffusely throughout the normal brain tissue. This feature contributes mainly to the failure of existing therapies. Deregulation of small GTPases signaling, in particular Rac1 activity, plays a key role in the invasive phenotype o...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Dove Medical Press
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218912/ https://www.ncbi.nlm.nih.gov/pubmed/25378937 http://dx.doi.org/10.2147/OTT.S67998 |