Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice

Synapse degeneration is an early and invariant feature of neurodegenerative diseases. Indeed, synapse loss occurs prior to neuronal degeneration and correlates with the symptom severity of these diseases. However, the molecular mechanisms that trigger synaptic loss remain poorly understood. Here we...

Descripción completa

Detalles Bibliográficos
Autores principales: Galli, Soledad, Lopes, Douglas M., Ammari, Rachida, Kopra, Jaakko, Millar, Sarah E., Gibb, Alasdair, Salinas, Patricia C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218967/
https://www.ncbi.nlm.nih.gov/pubmed/25318560
http://dx.doi.org/10.1038/ncomms5992

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218967/
https://www.ncbi.nlm.nih.gov/pubmed/25318560
http://dx.doi.org/10.1038/ncomms5992

Ejemplares similares