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Deficient Wnt signalling triggers striatal synaptic degeneration and impaired motor behaviour in adult mice
Synapse degeneration is an early and invariant feature of neurodegenerative diseases. Indeed, synapse loss occurs prior to neuronal degeneration and correlates with the symptom severity of these diseases. However, the molecular mechanisms that trigger synaptic loss remain poorly understood. Here we...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Pub. Group
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4218967/ https://www.ncbi.nlm.nih.gov/pubmed/25318560 http://dx.doi.org/10.1038/ncomms5992 |