Comparison of intracellular and secretion-based strategies for production of human α-galactosidase A in the filamentous fungus Trichoderma reesei

BACKGROUND: Trichoderma reesei is known as a good producer of industrial proteins but has hitherto been less successful in the production of therapeutic proteins. In order to elucidate the bottlenecks of heterologous protein production, human α-galactosidase A (GLA) was chosen as a model therapeutic...

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Detalles Bibliográficos
Autores principales: Smith, Wesley, Jäntti, Jussi, Oja, Merja, Saloheimo, Markku
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219008/
https://www.ncbi.nlm.nih.gov/pubmed/25344685
http://dx.doi.org/10.1186/s12896-014-0091-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219008/
https://www.ncbi.nlm.nih.gov/pubmed/25344685
http://dx.doi.org/10.1186/s12896-014-0091-y

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