ABCB4 is frequently epigenetically silenced in human cancers and inhibits tumor growth

Epigenetic silencing through promoter hypermethylation is an important hallmark for the inactivation of tumor-related genes in carcinogenesis. Here we identified the ATP-binding cassette sub-family B member 4 (ABCB4) as a novel epigenetically silenced target gene. We investigated the epigenetic regu...

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Detalles Bibliográficos
Autores principales: Kiehl, Steffen, Herkt, Stefanie C., Richter, Antje M., Fuhrmann, Liesa, El-Nikhely, Nefertiti, Seeger, Werner, Savai, Rajkumar, Dammann, Reinhard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219162/
https://www.ncbi.nlm.nih.gov/pubmed/25367630
http://dx.doi.org/10.1038/srep06899

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219162/
https://www.ncbi.nlm.nih.gov/pubmed/25367630
http://dx.doi.org/10.1038/srep06899

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