Iron Metabolism Regulates p53 Signaling through Direct Heme-p53 Interaction and Modulation of p53 Localization, Stability, and Function

Iron excess is closely associated with tumorigenesis in multiple types of human cancers, with underlying mechanisms yet unclear. Recently, iron deprivation has emerged as a major strategy for chemotherapy, but it exerts tumor suppression only on select human malignancies. Here, we report that the tu...

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Detalles Bibliográficos
Autores principales: Shen, Jia, Sheng, Xiangpeng, Chang, ZeNan, Wu, Qian, Wang, Sheng, Xuan, Zongliang, Li, Dan, Wu, Yalan, Shang, Yongjia, Kong, Xiangtao, Yu, Long, Li, Lin, Ruan, Kangchen, Hu, Hongyu, Huang, Ying, Hui, Lijian, Xie, Dong, Wang, Fudi, Hu, Ronggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219651/
https://www.ncbi.nlm.nih.gov/pubmed/24685134
http://dx.doi.org/10.1016/j.celrep.2014.02.042

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219651/
https://www.ncbi.nlm.nih.gov/pubmed/24685134
http://dx.doi.org/10.1016/j.celrep.2014.02.042

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