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PI3K Signaling and Stat92E Converge to Modulate Glial Responsiveness to Axonal Injury

Glial cells are exquisitely sensitive to neuronal injury but mechanisms by which glia establish competence to respond to injury, continuously gauge neuronal health, and rapidly activate reactive responses remain poorly defined. Here, we show glial PI3K signaling in the uninjured brain regulates base...

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Detalles Bibliográficos
Autores principales: Doherty, Johnna, Sheehan, Amy E., Bradshaw, Rachel, Fox, A. Nicole, Lu, Tsai-Yi, Freeman, Marc R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219656/
https://www.ncbi.nlm.nih.gov/pubmed/25369313
http://dx.doi.org/10.1371/journal.pbio.1001985