A Phylogeny-Based Benchmarking Test for Orthology Inference Reveals the Limitations of Function-Based Validation

Accurate orthology prediction is crucial for many applications in the post-genomic era. The lack of broadly accepted benchmark tests precludes a comprehensive analysis of orthology inference. So far, functional annotation between orthologs serves as a performance proxy. However, this violates the fu...

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Detalles Bibliográficos
Autores principales: Trachana, Kalliopi, Forslund, Kristoffer, Larsson, Tomas, Powell, Sean, Doerks, Tobias, von Mering, Christian, Bork, Peer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219706/
https://www.ncbi.nlm.nih.gov/pubmed/25369365
http://dx.doi.org/10.1371/journal.pone.0111122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4219706/
https://www.ncbi.nlm.nih.gov/pubmed/25369365
http://dx.doi.org/10.1371/journal.pone.0111122

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